The effect of methotrexate on enzymes induced following partial hepatectomy.
نویسندگان
چکیده
منابع مشابه
Resistance to Hepatotoxins Acquired by Hepatocytes during Liver Regeneration1
The appearance of resistance to a number of hepatotoxins ¡nprimary cultures of hepatocytes prepared at various time intervals up to 2 weeks after partial hepatectomy is the major focus in this study. Resistance to the cytocidal effect of aflatoxin Bi, 2-acetylaminofluorene, N-hydroxy-2-acetylaminofluorene, methotrexate, or methyl methanesulfonate shows a pro gressive increase until 48 hr and t...
متن کاملEffect of methotrexate and 5-fluorodeoxyuridine on ribonucleotide reductase activity in mammalian cells.
A number of studies in bacteria have indicated that deoxythymidine 5'-triphosphate may be a repressor or corepressor of ribonucleotide reductase. For determination of whether a similar regulating mechanism exists in mammalian cells, HeLa cells and partially hepatectomized rats were treated with either methotrexate, 5-fluorouracil, or 5-fluorodeoxyuridine in order to block thymidylate synthesis ...
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Objective(s): The objectives of the current study were to evaluate the effects of hepatic ischemia/reperfusion (IR) injury on the activity of antioxidant enzymes, biochemical factors, and histopathological changes in rat kidney, and to investigate the effect of crocin on IR-related changes. Materials and Methods: Thirty-two male Wistar rats were randomly allocated into four groups (n=8). The...
متن کاملThe effects of casticin and myricetin on liver damage induced by methotrexate in rats
Objective(s): In this study, we evaluated the therapeutic effects of casticin and myricetin on liver damage induced by methotrexate in rats.Materials and Methods: Thirty-six male rats were used for the study and divided into 6 groups: control, methotrexate, casticin, myricetin, casticin+methotrexate, and myricetin+methotrexate. It was performed by methotrexate (20 mg/kg single dose, IP) in met...
متن کاملResistance to hepatotoxins acquired by hepatocytes during liver regeneration.
The appearance of resistance to a number of hepatotoxins in primary cultures of hepatocytes prepared at various time intervals up to 2 weeks after partial hepatectomy is the major focus in this study. Resistance to the cytocidal effect of aflatoxin B1, 2-acetylaminofluorene, N-hydroxy-2-acetylaminofluorene, methotrexate, or methyl methanesulfonate shows a progressive increase until 48 hr and th...
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ورودعنوان ژورنال:
- Cancer research
دوره 29 2 شماره
صفحات -
تاریخ انتشار 1969